G.Z. Brown, Jeff Kline, Gwynne Mhuireach, Dale Northcutt and Jason Stenson argue in their recent commentary in Microbiome Journal that scientists can make the field of microbiology of the built environment more relevant and applicable to real-world design problems by addressing health and sustainability in tandem, and that practice-based research represents a promising approach to advancing knowledge of the indoor microbiome and translating it to architectural practice.